Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.
نویسندگان
چکیده
The first synthesis of 1-deaza-pyridoxal 5'-phosphate (2-formyl-3-hydroxy-4-methylbenzyl phosphate) is described. The chemoenzymatic approach described here is a reliable route to this important isosteric pyridoxal phosphate analogue. This work enables elucidation of the role of the pyridine nitrogen in pyridoxal 5'-phosphate dependent enzymes.
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عنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 20 4 شماره
صفحات -
تاریخ انتشار 2010